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Friday 29 September, 2000

EVOTEC BioSystems

Offer for OAI: Offer Update

EVOTEC BioSystems AG
29 September 2000

Not for release, publication or distribution in or into the United States,
Australia, Canada or Japan.

    Recommended Offer by Lehman Brothers on behalf of EVOTEC BioSystems AG
      ('EVOTEC') for Oxford Asymmetry International plc ('OAI') declared
                         unconditional in all respects

Further to its announcement yesterday, EVOTEC announces that the Frankfurt
Stock Exchange has approved the prospectus required to be published in
connection with the listing of the New EVOTEC Shares on the Neuer Markt. All
the remaining conditions to the Offer have been satisfied or waived.
Accordingly, EVOTEC is pleased to announce that the Offer has been declared
unconditional in all respects.

OAI Shareholders who wish to accept the Offer, but have not already done so,
should return their completed Form(s) of Acceptance in accordance with the
instructions set out in the Offer Document as soon as possible. The Offer will
remain open until further notice.

Save as disclosed above, neither EVOTEC nor any party deemed to be acting in
concert with EVOTEC has acquired or agreed to acquire any OAI Shares (or
rights over such shares) since 18 July 2000, the last day prior to the
commencement of the Offer Period nor did any such person hold any OAI Shares
(or rights over such shares) on 18 July 2000.


Lehman Brothers                                      Tel:  +44 (0)20 7601 0011
Warwick Ball

Definitions used in the offer document dated 12 August 2000 have the same
meanings when used in this announcement, unless the context requires

Lehman Brothers, which is regulated in the UK by The Securities and Futures
Authority Limited, is acting for EVOTEC BioSystems AG in connection with the
Offer and no-one else and will not be responsible to anyone other than EVOTEC
BioSystems AG for providing the protections afforded to customers of Lehman
Brothers, nor for providing advice in relation to the Offer.

The Offer is not being made, directly or indirectly, in or into Australia,
Canada or Japan, and it may not be accepted in or from Australia, Canada or
Japan.  In addition, the Offer is not being made, directly or indirectly in or
into the United States, and, subject to certain exceptions, the Offer may not
be accepted from the United States.

The New EVOTEC Shares proposed to be issued in connection with the Offer will
not be registered under the U.S. Securities Act of 1933, as amended.  This
announcement does not constitute an offer of securities for sale in the United
States.  No public offering of securities will be made in the United States in
connection with the Offer.


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